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Spravato / Esketamine

Spravato / Esketamine


SPRAVATO is a prescription nasal spray medication, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults.

Get to Know SPRAVATO

  • Studied in adults with treatment-resistant depression
  • Self-administered Nasal spray
  • Taken with a daily oral antidepressant
  • After taking SPRAVATO™, a healthcare professional will monitor you for at least two hours for possible side effects
  • Because of the risks for possible side effects, abuse and misuse, SPRAVATO can only be administered at healthcare settings certified in the SPRAVATO Risk Evaluation and Mitigation Strategy (REMS) Program, and to patients enrolled in the program.

Preparing for Treatment

You’ll need to plan for rides to and from our certified SPRAVATO treatment center as you should not drive or operate machinery until the day after a treatment session, following a restful sleep. You may want to bring a book, a relaxing playlist or another form of entertainment for the session because your doctor will monitor you for at least two hours after treatment.

How to Use SPRAVATO Nasal Spray

You will administer SPRAVATO yourself under the supervision of a healthcare professional, who will show you how to use the nasal spray device.

SPRAVATO Side Effects

The most common side effects that can occur during and after taking SPRAVATO include:

– Dissociation – Nausea

– Dizziness – Vomiting

– Sedation (sleepiness) – Spinning sensation

– Anxiety  – Lack of energy

– Increased blood pressure  – Feeling drunk

– Reduced sense of touch and sensation

Increased blood pressure (temporary)